Abstract
In the field of tissue engineering, there are several issues to consider when designing biomaterials for implants, including cellular interaction, good biocompatibility, and biochemical activity. Biomimetic mineralization has gained considerable attention as an emerging approach for the synthesis of biocompatible materials with complex shapes, categorized organization, controlled shape, and size in aqueous environments. Understanding biomineralization strategies could enhance opportunities for novel biomimetic mineralization approaches. In this regard, mussel-inspired biomaterials have recently attracted many researchers due to appealing features, such as strong adhesive properties on moist surfaces, improved cell adhesion, and immobilization of bioactive molecules via catechol chemistry. This molecular designed approach has been a key point in combining new functionalities into accessible biomaterials for biomedical applications. Polydopamine (PDA) has emerged as a promising material for biomaterial functionalization, considering its simple molecular structure, independence of target materials, cell interactions for adhesion, and robust reactivity for resulting functionalization. In this review, we highlight the strategies for using PDA to induce the biomineralization of hydroxyapatite (HA) on the surface of various implant materials with good mechanical strength and corrosion resistance. We also discuss the interactions between the PDA-HA coating, and several cell types that are intricate in many biomedical applications, involving bone defect repair, bone regeneration, cell attachment, and antibacterial activity.
Highlights
In the field of bone tissue engineering, designing the appropriate material for implantation is a vital aspect, which requires a comprehensive understanding of material composition, physical properties, structures to mimic the properties of the natural human bone
The results indicated that the PDA-modified AH-Ti surface was a superior substrate for human gingival fibroblast (HGF) adhesion, spread, and proliferation
The molecular structure, stability, conformity, and mechanical strength of the PDA coating in physiological environments make it more relevant to biomimetic mineralization
Summary
In the field of bone tissue engineering, designing the appropriate material for implantation is a vital aspect, which requires a comprehensive understanding of material composition, physical properties, structures to mimic the properties of the natural human bone. HA for bone tissue engineering research, as well as practical applications [1]. HA, significantly significantly improving their properties for the practical application in bone tissue engineering. Over the last 10 years, unique its material substitute is still controversial, the in assisted surface modification is this expanding method has gained much attention from researchers, with many publications on a wide range of applications in osteogeneration. Over the last 10 years, this unique method has gained much attention implant materials, including ceramics, to improve bothmaterials, their physical properties from researchers, with many metals, publications on apolymers, wide range of implant including metals, and biological activities Hydroxyapatite approach to improving the properties biological properties for boneFunctionalization tissue engineering materials. Physical properties and biological properties for bone tissue engineering materials
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