Abstract
Biofilm-based bacterial infections are a significant health threat due to their chronic nature and lack of susceptibility to both the host immune response and to treatment with conventional antibiotics. There are numerous complex and interrelated mechanisms underling this tolerance, and strategies to overcome them are required in order to combat the considerable threat posed by biofilm-based bacterial infections. Several such strategies that have been explored toward the eradication of biofilm-based bacterial infections are discussed in this chapter. One strategy involves developing new antibiotics that are active against biofilm cells, while other approaches center on enhancing the activity of conventional antibiotics against biofilm cells with compounds that interfere with quorum sensing and other bacterial signaling and communication pathways, target biofilm-specific genes, or target the biofilm matrix.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.