Abstract
Novel C2-symmetric diiminosphosphoranes and diketimines are useful ligands for Pd-and Cu-catalyzed C-C bond forming reactions, Angermund's molecular modeling based on accessible molecular surface serving as a guide in predicting catalyst activity. The first highly enantioselective diphosphites as ligands in Rh-catalyzed hydrogenation are also described, the selectivity principle being based on in situ selection of conformational enantiomers. Finally, a systematic study of chiral diphosphonites reveals that ferrocene-based derivatives are ideal in hydrogenation and certain conjugate addition reactions. These methods are compared to biocatalytic strategies based on the creation of enantioselective biocatalysts by in vitro evolution, a rational process which is independent of the catalyst structure or mechanism.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
