Abstract
The cleavage of the glycosidic bond in glycoconjugates is an important activity in biological systems. The enzymes catalyzing this activity are termed as “glycoside hydrolases” (GH). About 1% of the genome in organisms are encoded by GHs. Researchers have put in tremendous amount of effort in understanding the mechanism of GHs and the effect of their function on chronic diseases such as tuberculosis and diabetes. A variety of therapeutics such as Acarbose and Miglitol have been developed based on these studies which pave the way for further development in the field. This chapter focuses on different strategies that can be considered for designing carbohydrates as potential inhibitors of glycoside hydrolases.
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