Abstract
This paper describes two strategies for automated lidocaine infusion in the treatment of ventricular arrhythmias. In the first strategy, the drug is administered to achieve a target serum concentration using adaptive control based on sparse concentration measurements. In the second strategy, the drug infusion rate is adjusted using closed-loop control with a goal of reducing the rate of premature ventricular contractions (PVCs) to 30 PVCs/hour subject to infusion rate constraints that limit the range of predicted lidocaine serum concentrations during closed-loop control.
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