Abstract
A rapid and enormously professional new-flanged 3,5-disubstituted triazole derivatives were synthesized by the one-pot five-component condensation reaction in the course of transesterification followed by the Biginelli/Click reaction in aqueous medium using magnetic CuFe2O4 NPs as heterogeneous catalyst beneath ultrasonic acceleration in aqueous medium. The synthesized 3,5-disubstituted triazole derivatives were finely characterized and the characterized desired target molecules were employed for the quantum chemical calculations for each reactant and product have been well thought-out using density functional theory. Furthermore, the molecular docking and ADMET revision of all the derivatives have been achieved as digestive enzyme and Cathepsin-B inhibitors and their connections with BSA to treat different diseases.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
