Abstract
Magnesium (Mg) and its alloys have attracted much attention as a promising candidate for degradable implant applications however the rapid corrosion of magnesium inside the human body greatly limits its use as an implant material. Therefore, coating the alloy surface with a multifunctional film is a promising way to overcome the drawbacks. Here we propose for the first time a multifunction layer coating to enhance the cell viability, antibacterial property and decelerated corrosion rates to act as a novel material to be used for degradable implant Applications. For that, the magnesium alloy (AZ31) was first treated with hydrofluoric acid (HF) and then dopamine tris Hydrochloric acid (tris-HCL) solution. The reducing catechol groups in the polydopamine (PD) layer subsequently immobilize silver/gold ions in situ to form uniformly dispersed Ag/Au nanoparticles on the coating layer. The successful formation of Ag/Au nanoparticles on the HF-PD AZ31 alloy was confirmed using XPS and XRD, and the morphology of all the coated samples were investigated using SEM images. The alloy with HF-PDA exhibit enhanced cell attachment and proliferation. Moreover, the nanoparticle immobilized HF-PD alloy exhibited dramatic corrosion resistance enhancement with superior antibacterial properties and accountable biocompatibility. Thus the result suggest that HF-PD Ag/Au alloy has great potential in the application of degradable implant and the surface modification method is of great significance to determine its properties.
Highlights
Mg is highly biocompatible and can naturally dissolve in vivo[5,6]
The scanning electron microscope (SEM) image shows that the morphology of bare alloy possesses a passive layer on the surface with cracks and pores; these defects could be unfavorable for long-term corrosion protection, as the corrosive media could penetrate through these defects, leading to an acceleration of the contact between the surface and the corrosive media
PD was successfully polymerized on a hydrofluoric acid (HF)-pre-treated AZ31-alloy surface using a simple and easy immersion method
Summary
Alloy for enhanced viability, antibacterial property and decelerated corrosion rates for degradable implant Applications. We propose for the first time a multifunction layer coating to enhance the cell viability, antibacterial property and decelerated corrosion rates to act as a novel material to be used for degradable implant Applications. The improvement of apatite mineralization of PDA bioceramics may be the important reason to enhance the adsorption of serum proteins and further improve attachment, proliferation, differentiation and bone-related gene expression of cells[25] From these findings, it was proved that PD comprises effective adhesive, cytocompatibility, and anticorrosive activities among the organic and inorganic coatings. The results revealed that this kind of coating improved the corrosion resistance, but it released the Ag and Au NPs from the alloy surface, thereby providing an excellent antibacterial effect against both gram-positive and gram-negative bacteria species with a minimum toxicity against mammalian cells. The balance between the antibacterial effect and the cell response in consideration of the degradation process makes it an alternative in the application of the surface modification of the Mg alloy in degradable implant applications, and it is anticipated that the proposed surface-modification method can greatly contribute towards the progress of the development of Mg-alloy for medical devices
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
