Abstract
Covalently closed circular plasmid DNA was modified by benzo[ a]pyrene diolepoxide and incubated with partially purified fractions of the Escherichia coli uvr + gene products. Strand breaks were introduced into the modified DNA by the uvrABC endonuclease; on average, one break was formed for each bound benzo[ a]pyrene residue in the DNA. These results are direct evidence that benzo[ a]pyrene adducts in DNA are acted upon by the same repair enzyme as those that handle UV-induced lesions in DNA.
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