Abstract
Previous studies have demonstrated that there are numerous laboratory strains of scrapie, that can be distinguished on the basis of their disease characteristics in panels of inbred mouse strains. The main criteria used in these strain typing studies are the incubation periods of the disease and the distribution of pathological changes seen in the brains of these mice, expressed in the form of a “lesion profile”. Studies of scrapie strain characteristics on passage in hosts of different species or genotypes have shown that the agent contains an informational component that is independent of the host. In recent years strain typing methods have been used to explore epidemiological links between spongiform encephalopathies occurring in different species.
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