Strain-Programmed Adhesive Patch for Accelerated Photodynamic Wound Healing.

Abstract

As an alternative to tissue adhesives, photochemical tissue bonding has been investigated for advanced wound healing. However, these techniques suffer from relatively slow wound healing with bleeding and bacterial infections. Here, we present the versatile attributes of afterglow luminescent particles (ALPs) embedded in dopamine-modified hyaluronate (HA-DOPA) patches for accelerated wound healing. ALPs enhance the viscoelastic properties of the patches, and the photoluminescence (PL) and afterglow luminescence (AL) of ALPs maximize singlet oxygen generation and collagen fibrillogenesis for effective healing in the infected wounds. The patches are optimized to achieve the strong and rapid adhesion in the wound sites. In addition, the swelling and shrinking properties of adhesive patches contribute to a non-linear behavior in the wound recovery, playing an important role as a strain-programmed patch. The protective patch prevents secondary infection and skin adhesion, and the patch seamlessly detaches during wound healing, enabling efficient residue clearance. In vitro, in vivo, and ex vivo model tests confirm the biocompatibility, antibacterial effect, hemostatic capability, and collagen restructuring for the accelerated wound healing. Taken together, this research collectively demonstrates the feasibility of HA-DOPA/ALP patches as a versatile and promoting solution for advanced accelerated wound healing, particularly in scenarios involving bleeding and bacterial infections. This article is protected by copyright. All rights reserved.