Strain identification of Mycobacterium tuberculosis in multidrug-resistant tuberculosis (MDR-TB) patients at Undata Hospital, Palu, Central Sulawesi

Abstract

MDR-TB is a tuberculosis disease resistant to the two most effective anti-TB drugs, rifampin and isoniazid. MDR-TB is a threat to TB control. This study aims to identify the Mycobacterium tuberculosis strain in MDR-TB patients at Undata Hospital in Palu, Central Sulawesi. This type of research is descriptive and observational with a cross-sectional design. The study was conducted in Palu City, Donggala Regency, and Sigi Regency from April–June 2021. The sample in this study consisted of 22 patients who had undergone MDR-TB treatment from 2019 to 2020. The results showed that 55% of the patients with MDR-TB lived in Palu City, 27% in Donggala Regency, and 18% in Sigi Regency. Out of the 22 patients, 13 were men (59%) and nine were women (41%). Based on the results of the examination of Mycobacterium tuberculosis culture, three samples from patients with MDR-TB were positive for M. tuberculosis. The results of the spoligotyping examination showed that the strain belonged to the Beijing family. Identifying the type of M. tuberculosis strain through spoligotyping examination should be carried out in TB patients who have not undergone MDR-TB treatment or those who have failed treatment and are still found to be positive for M. tuberculosis bacteria.