Abstract
Several inbred strains of mice differed in their ability to respond to Type III pneumococcal polysaccharide (SIII) at both the circulating antibody and cellular levels. The PFC response to SIII was qualitatively similar for all strains of mice tested in that only direct PFC were detected. The kinetics of the response were also similar for several of the inbred strains of mice but differed for random-bred mice. The ability of certain strains of mice to respond well to SIII was dominant over low responsiveness and was not associated with the H-2 locus in contrast to the control of responsiveness exerted by this locus for several polypeptide and protein antigens.
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