Abstract
It is well known that the oral administration of di-2-ethylhexyl phthalate (DEHP) produces severe seminiferous tubular atrophy in rats, but mice are far less sensitive. In the present experiment, we demonstrated that one strain of mice derived from ICR mice, Crj:CD-1, was very sensitive to DEHP-induced testicular injury. This atrophy was accompanied by lowered zinc concentration and lactate dehydrogenase isozyme X in the testis. This fact and the effect of genetic background will need to be considered for assessing the risk of testicular toxicity in men exposed to phthalate esters.
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