Abstract
AbstractThe pentasaccharide repeating unit rich in 2-acetamido sugars corresponding to the O-antigenic polysaccharide from enteropathogenic Escherichia coli (E. coli) has been synthesized as the p-methoxyphenyl glycoside in excellent yield using a sequential glycosylation strategy. Regioselective glycosylation, use of a single monosaccharide intermediate in multiple glycosylations, and use of thioglycosides as glycosyl donors in the presence of a combination of N-iodosuccinimide (NIS) and perchloric acid supported over silica (HClO4–SiO2) are key components of the synthetic strategy. All glycosylation reactions were high-yielding with excellent stereochemical outcome.
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