Straightforward synthesis of di-, tri- and tetracyclic lactams via catalytic Pauson–Khand and Alder–Ene reactions of MCR products

Abstract

Novel enynes have been synthesized by three-component coupling reactions of aldehydes, dienophiles and amides (AAD-reaction; see preceding manuscript) and were converted via catalytic Pauson–Khand- and Alder–Ene-reactions to give functionalized di-, tri- and tetracyclic lactam derivatives in good yields.