Abstract
Synthesis of a thiol-reactive telechelic polystyrene and conjugation of cysteine is reported. A dimethylfulvene-protected maleimide-functionalized atom transfer radical polymerization (ATRP) initiator (3) was synthesized, and the thermostability was compared to the analogous furan-protected initiator (1) by thermogravometric analysis (TGA). The former protecting group was stable to a higher temperature than the latter in the bulk phase (143 °C vs 125 °C) and thus was investigated as an initiator for the ATRP of styrene. Kinetic studies of the polymerization of styrene mediated by copper(I)/N,N,N‘,N‘ ‘,N‘ ‘-pentamethyldiethylenetriamine (PMDETA) indicated that the reaction proceeded in a controlled manner with high initiator efficiency (92%). Polystyrene with a number-average molecular weight (Mn) of 2530 Da and a narrow polydispersity index (PDI) of 1.15 was then synthesized and subjected to atom transfer radical (ATR) coupling to form the bis-functionalized polymer. Gel permeation chromatography (GPC) an...
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