Abstract

Background: Restrictive strabismus is a common feature of Thyroid-Related Ophthalmopathy (TRO) causing intractable diplopia. We reviewed the surgical outcome for TRO patients. Methods: We retrospectively reviewed patients of TRO who underwent strabismus surgery from January, 1998 to September, 2012. Preoperative characteristics were recorded such as age, sex, disease severity, presence of compressive optic neuropathy or elevation of intraocular pressure, symmetry of orbitopathy, duration between onset of TRO and surgery, smoking status, and treatment. The length of muscle recession and the numbers of strabismus surgeries was recorded for further analysis. Results: Twenty-four patients were enrolled with twelve female and twelve male in a mean age of 55.5 years (SD + 10.71). The mean number of surgery was 1.29 (SD + 0.46). Patients with asymmetric involvement at onset, presence of elevated intraocular pressure, and longer intervals between the onset of TRO and first surgery needed significantly more surgeries to correct strabismus. Factors such as age, gender, smoking status, medical treatment before surgery, presence of compressive optic neuropathy or previous orbital decompression procedure had no statistically significant effect on the number of surgery required. Conclusion: Strabismus surgery showed favorable outcomes in correcting diplopia induced by thyroid-related ophthalmopathy. The average number of surgery needed is 1.29 (±0.46) in this study, and the mean surgical effect we got was 4.09+0.26 PD/mm of rectus muscle recession.

Highlights

  • Thyroid-related ophthalmopathy [1]/ orbitopathy (TRO), known as thyroid associated ophthalmopathy [2]/orbitopathy (TAO) [3], thyroid eye disease (TED) [4,5], or Graves’s ophthalmopathy [6]/ orbitopathy [7], is considered an autoimmune disease which is characterized by chronic inflammation of orbital soft tissue, extraocular muscles, conjunctiva and even eyelids [1,8]

  • D.R suggested that a stable postoperative alignment is more likely reached after an extended period of stable preoperative alignment, and it minimizes the need for repeated strabismus surgery [7]

  • In this study we found that the presence of secondary glaucoma, unilateral involvement at onset, and longer intervals between Thyroid-Related Ophthalmopathy (TRO) onset and surgery were significantly correlated with increased numbers of surgeries

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Summary

Introduction

Thyroid-related ophthalmopathy [1]/ orbitopathy (TRO), known as thyroid associated ophthalmopathy [2]/orbitopathy (TAO) [3], thyroid eye disease (TED) [4,5], or Graves’s ophthalmopathy [6]/ orbitopathy [7], is considered an autoimmune disease which is characterized by chronic inflammation of orbital soft tissue, extraocular muscles, conjunctiva and even eyelids [1,8]. It may cause social and visual problems to patients by disturbing appearance and visual function.

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