Store-Independent Calcium Entry and Related Signaling Pathways in Breast Cancer.

Mohamed Chamlali,Halima Ouadid-Ahidouch,Lise Rodat-Despoix

doi:10.3390/genes12070994

Mohamed Chamlali, Halima Ouadid-Ahidouch + Show 1 more

Open Access

https://doi.org/10.3390/genes12070994

Copy DOI

Journal: Genes	Publication Date: Jun 29, 2021
Citations: 10	License type: CC BY 4.0

Affiliation: University of Picardie Jules Verne

Abstract

Known as a key effector in breast cancer (BC) progression, calcium (Ca2+) is tightly regulated to maintain the desired concentration to fine-tune cell functions. Ca2+ channels are the main actors among Ca2+ transporters that control the intracellular Ca2+ concentration in cells. It is well known that the basal Ca2+ concentration is regulated by both store-dependent and independent Ca2+ channels in BC development and progression. However, most of the literature has reported the role of store-dependent Ca2+ entry, and only a few studies are focusing on store-independent Ca2+ entry (SICE). In this review, we aim to summarize all findings on SICE in the BC progression field.

Highlights

Cancers are a major public health problem due to their incidence and, more their mortality
The most known is the store-operated Ca2+ entry (SOCE) pathway which is regulated by the activation of the Ca2+ release-activated channels encoded by Orai channels via stromal interaction molecule (STIM) proteins [7]
We aimed to summarize the different studies which have shown the role of store-independent Ca2+ entry (SICE) in the regulation of breast cancer (BC) processes

Summary

Introduction

Cancers are a major public health problem due to their incidence and, more their mortality. The most known is the store-operated Ca2+ entry (SOCE) pathway which is regulated by the activation of the Ca2+ release-activated channels encoded by Orai channels via stromal interaction molecule (STIM) proteins [7]. It is well known in the literature that these channels play critical roles in carcinogenesis, including BC [8]. Recent studies have reported the role of store-independent Ca2+ entry (SICE) in regulating BC processes and several hallmarks of BC. We aimed to summarize the different studies which have shown the role of SICE in the regulation of BC processes

Orai Channels

TRP Channels

Voltage-Gated Calcium Channels

Conclusions