Stopping power measurement for proton therapy by combining proton radiography and X-ray CT

Abstract

Exact information on the relative stopping power (RSP) of the high-energy proton in the human body is necessary to precisely control radiation dose and position in proton beam therapy. RSP has been estimated by converting the X-ray computed tomography (CT) information. However, it causes up to 5% uncertainty in the RSP measurements because of the fundamental difference between the X-ray and proton interaction. Therefore, this study investigates a scheme of the RSP distribution measurement in the human body with a combination of X-ray CT and proton radiography with beam injection to a single direction. We studied the accuracy of the RSP measurement using GEANT4 simulation with silicon trackers, crystal calorimeter, and proton beam. The RSP accuracy has been generally measured below 1% from the reference values for simple objects with multi cylindrical shapes. The simulation results present the requirements of a proton tracking system on the spatial resolution and the acquisition rate. We developed a tracking detector prototype consisting of double-sided silicon strip detectors and amplifier–shaper–discriminator LSI chips. We evaluated the performance with an 80 MeV proton beam in Cyclotron and Radioisotope Center, Tohoku University. It succeeded in reconstructing a proton trajectory with 160 kHz and fulfilled the requirements to realize the proposed scheme. Furthermore, this study describes the detailed study of the scheme of the RSP measurement and the beam test of the tracking system prototype.