Abstract
With the stopped-flow multidimensional gas chromatographic technique enantiomerization barriers of ΔG#(T)=70–200 kJ/mol can easily be determined. First, the racemic mixture is separated by gas chromatography on a chiral stationary phase, then one enantiomer is transferred into a heated empty reactor column where enantiomerization is performed on-line in an achiral environment in the gas phase, and finally the enantiomerized fraction is separated in a second chiral column. The enantiomerization barrier ΔG (T) can be calculated from the enantiomerization time, the observed enantiomeric ratio, and the enantiomerization temperature. Moreover, by calculating ΔG#(T) at different temperatures, ΔH# and ΔS# are accessible. With this method atropisomeric polychlorinated biphenyls, a chiral allene, and a chiral aziridine were investigated. ©1999 John Wiley & Sons, Inc. J Micro Sep 11: 475–479, 1999
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