Abstract
Actin-based cell motility is essential to many biological processes. We build simplified computational model and perform stochastic simulation to study the growth of lamellipodia-like branched filamentous network. Here we investigate how capping proteins and anti-capping proteins affect the speed of protrusion and the nucleation of filaments in the model system. Phase diagram showing the regimes of motility enhancement and motility inhibition is presented. Furthermore, we discuss filament length distribution and its implication in the formation of filopodia from lamellipodial network.
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