Abstract
A wealth of molecular, cellular, and biochemical information on a vast array of cellular processes is now complemented by a treasure trove of genomic and proteomic information. Can whole pictures of biological functions now emerge from these disparate parts? The special issue of Science magazine focuses on the interdisciplinary field of Systems Biology (http://stke.sciencemag.org/cgi/content/summary/vj_sci;295/5560/1661), where biologists, chemists, engineers, mathematicians, physicists, and computer scientists have been trying to grapple with assembling these pieces into broader schemes, from the level of gene expression to the more complex levels of cell, tissue, and organism function. This issue of the STKE explores how a new generation of analytical tools and modeling is helping to break ground in understanding complex cellular signaling mechanisms.
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