Abstract
Polymeric nanoparticles with unique properties are regarded as the most promising materials for biomedical applications including drug delivery and in vitro/in vivo imaging. Among them, stimulus-responsive polymeric nanoparticles, usually termed as “intelligent” nanoparticles, could undergo structure, shape, and property changes after being exposed to external signals including pH, temperature, magnetic field, and light, which could be used to modulate the macroscopical behavior of the nanoparticles. This paper reviews the recent progress in stimulus-responsive nanoparticles used for drug delivery and in vitro/in vivo imaging, with an emphasis on double/multiple stimulus-responsive systems and their biomedical applications.
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