Abstract
It is suggested that chlorpromazine may reduce the significance of stimuli to an animal, and that if this were so, it would follow that the effects of chlorpromazine might be offset by arranging for stimulus significance to be increased. The effects of 0–075 mg/kg of chlorpromazine on the acquisition of one-trial passive avoidance learning in mice are described; when the experimental subjects were given prior experience, in a T-maze, of the black-white discriminanda used in establishing one-trial learning, the extent of the drug-induced suppression of learning was reduced. The results are discussed as being consistent with a chlorpromazine induced reduction of stimulus significance.
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