Abstract
Well-defined amphiphilic poly(ionic liquid) (PIL) block copolymers with stimuli-responsive were successfully synthesized through the combination of atom transfer radical polymerization (ATRP) and a 'Click' chemistry approach. These copolymers were able to self-assemble into spherical nanoparticles in aqueous solution and the micelle assembly and disassembly were induced by an external light irradiation. The size was uniform and ranges approximately from 28 to 100 nm. The DOX-loaded polymer micelles have good stability in vitro, and the drug release profile shows that release was clearly regulated by pH and photo-responsive. In addition, cell counting assay kit-8 (CCK-8) showed that the drug delivery system of this study had a high inhibition rate to tumor cells. Confocal laser scanning microscopy (CLSM) images and flow cytometric analysis of 4T1 cells showed efficiently absorption due to receptor-mediated high specific affinity of CD44 for hyaluronic acid. Therefore, drug-loaded micelles exhibit enhanced antitumor effects in vitro and vitro. These results suggested that PIL block copolymer dependent drug delivery system will provide inform the design of potential drugs for cancer treatment.
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