Abstract
Due to the great progress of nanotechnology in clinical application, numerous types of small drug delivery systems have been developed and utilized to improve the efficacy of anti-cancer drugs. Due to their excellent physiological properties, stimuli-responsive systems or “smart” systems that are able to release the drug at the desire site within the human body have received much interest in biomedical and cancer drug delivery. Herein, the recent advances and progress in the design and development of various stimuli-responsive drug delivery systems and their mechanisms of action are discussed in details.
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