Stimuli-responsive liposome and drug release

Abstract

Stimuli-responsive liposomes are a promising class of nanomedicine with the potential to provide site-specific chemotherapy. The liposomes have the potential not only to provide site-specific chemotherapy, but also to trigger drug release. Thus it is greater spatial and temporal control in the therapy. Their structure, configuration and other characteristics can be changed under certain in vivo or in vitro stimulus, including heat, light, magnetism and pH changes, and finally carried drugs in the liposome can be released. They can reduce or avoid premature drug release before the liposome reach target site and improve drug release efficiency at target sites. The structure, features and functions of the stimulus response liposomes are summarized. The relative thermal, light, magnetism and pH stimuli responsive properties are reviewed, and the mechanism of stimulate release drug are discussed.