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Abstract
A homogeneous electrochemiluminescence (ECL) sensing system was designed for highly sensitive detection of tumor exosomes by combining stimuli-responsive DNA microcapsules with target recycling amplification. In this work, CdS quantum dots (QDs) as ECL emitters were sealed in the inner pores of DNA microcapsules with crosslinking DNA shells. In the presence of target exosomes, S4-combined exosomes were formed and then hybridized with the crosslinking base sequences of DNA shells. Thus, DNA microcapsules were effectively unlocked, leading to the release of CdS QDs. The target exosomes-dependent amount of release CdS QDs could be conveniently monitored by ECL technique. With enzymatic recycling binding of target amplification, the proposed homogeneous ECL sensor possessed a wide detection range, high sensitivity and selectivity in complex biological samples.
Published Version
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