Stimuli-induced Pulsatile or Triggered Release Delivery Systems for Bioactive Compounds

Abstract

As is frequently found in the living body, many vital functions are regulated by pulsed or triggered release of bioactive substances at a specific site and time. Thus it is important to develop new drug delivery devices to achieve pulsed delivery of a certain amount of drugs in order to mimic the function of the living systems to minimize the undesired side effects. The pulsed or triggered delivery systems are designed to alter their rate of drug delivery in response to stimuli such as changes in a specific molecule, a magnetic or electric field, temperature, light or mechanical forces. Such systems are suitable for the release of therapeutics that benefit from non-constant plasma concentrations. In this article, several types of drug delivery systems which cause the pulsed or triggered release of bioactive compounds due to certain external stimuli, mostly focuses on thermally-, electrically- and magnetically- induced release are described in detail. The recent patents on various delivery systems which release the active compounds only with the external stimuli are described in detail. Keywords: Pulsatile release, triggered release, bioactive compounds, reservoir devices, thermo-responsive, electro-responsive