Abstract
Superoxide radical ( .O − 2) production was measured spectrophotometrically using NADH and lactate dehydrogenase (LDH) in a xanthine oxidase(XOD) plus hypoxanthine (HX) system and in an isolated guinea pig macrophages system. Sodium platinum (IV) chloride (Na 2PtCl 6: 2.5 × 10 −4−1 × 10 −3M) enhanced the production of .O 2 − in both systems (2–10 times). The degree of the enhancement was dependent on incubation time, basal level of .O 2 − production and concentration of Na 2PtCl 6. The stimulated .O 2 − production in the XOD system was inhibited by luminol ( O-aminophtalhydrazide) and that in the macrophages was inhibited by an anti-inflammatory drug, Diclofenac sodium (Dc). These results show that platinum (IV) ion is either a potent stabilizer of .O 2 − or a stimulator of .O 2 − production as are paraquat or streptonigrin. This specific character of platinum (IV) ion may explain its bactericidal and inflammation-inducing properties.
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