Abstract
A possible effect of LII or hCG on testicular prolactin receptor levels was investigated in hypophysectomized adult rats. Hypophyseetomy leads to a progressive decrease of testicular prolactin receptor content to ‘\�25% of that of controls 12 days after surgery. In animals injected3 times a day for 10 days with highly purifiedpreparations of ovine LII or hCG, prolactin receptor levelsincreasedfrom 21 4 to 41 ± 4 and 71 7 fmol/testis, respectively (P<0.01 for both). The increase in the number of testicular prolactin receptor levels observed after treatment with hCG in hypophysectomized rats could not be duplicated by injection of estradiol-173 (0.5 pg), testosterone (200 pg) or 5u-dihydrotestosterone (200 pg) given twice a day for 5 days. Moreover, these steroids do not interfere with the stimulation of prolactin binding induced by hCG. Since treatment with prolactin is well known to stimulate testicular LII binding and steroidogenesis, the present data provide further evidence for a close interaction between prolactin and LII in the control of the testicular levels of receptors for these two hormones and their subsequent role in the control of testicular functions.
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