Abstract
Enhancement of aniline hydroxylation was observed by the addition of cyanide in rat liver microsomes. The enhancing effect of cyanide on aniline hydroxylation activity was also observed in rabbit liver microsomes, but not in guinea pig liver microsomes. Aniline stimulated the reoxidation of reduced nicotinamide adenine dinucleotide (NADH)-reduced cytochrome b5. The stimulation of cytochrome b5 reoxidation by aniline was most remarkable in liver microsomes from desaturase-induced rats followed by that from fed and fasted rats. The increment in cytochrome b5 reoxidation by aniline in all groups of rats was inhibited by the simultaneous addition of cyanide, However, the stimulatory effect of cyanide on aniline hydroxylation in fasted rat was not different from that observed in desaturase-induced rat. In addition, the effect of cyanide on aniline hydroxylation was suggested to be reversible.
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