Abstract
The effect of inositol 1,4,5 trisphosphate (IP 3) has been investigated on the cAMP-induced phosphorylation of the 23-Kd protein involved in platelet calcium fluxes by isolated membrane vesicles. The studies were conducted using the catalytic subunit of the cAMP-dependent protein kinase (C. Sub.). A dose-dependent stimulation of the 23 Kd protein phosphorylation induced by C. Sub. was initiated by IP 3 with a half-maximal effect of 0.5 μM. The maximal effect was observed after 1–2 min. The effect was detected in the absence of Ca 2+ and in the presence of phosphatase inhibitors. These results can suggest that the 23 Kd is an associated protein to the IP 3 receptor in human platelets.
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