Abstract
Background Unilateral ureteral obstruction (UUO) is characterized by progressive renal atrophy, tubular apoptosis and tubulointerstitial fibrosis. Pharmacological stimulation of soluble guanylate cyclase (sGC) and subsequent cGMP production have recently been found to be renoprotective. In this study, the sGC stimulator BAY 41-8543 was given to rats after relief of UUO in order to analyze the effects of enhanced NO/sGC/cGMP signaling on the subsequent renal disease recovery, concerning the renal atrophy, tubular apoptosis and tubulointerstitial fibrosis.
Highlights
Harm PetersAddress: Department of Nephrology and Center of Cardiovascular Research, Charité-Universitätsmedizin, Berlin, Germany
Unilateral ureteral obstruction (UUO) is characterized by progressive renal atrophy, tubular apoptosis and tubulointerstitial fibrosis
4th International Conference of cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2210-9-S1-info.pdf
Summary
Address: Department of Nephrology and Center of Cardiovascular Research, Charité-Universitätsmedizin, Berlin, Germany. Published: 11 August 2009 BMC Pharmacology 2009, 9(Suppl 1):P71 doi:10.1186/1471-2210-9-S1-P71. 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2210-9-S1-info.pdf
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