Abstract

SummaryYoung rats on a diet containing not more than 0.001 ppm boron were used to study the effect of administered boric acid on the synthesis of nuclear liver RNA. A 30-min pulse of [6-14C]-orotic acid resulted in a higher incorporation of 14C in liver RNA when borate was given intraperitoneally. This increased incorporation was diminished when the diet contained 1 ppm boron as boric acid. An attempt to determine the effect of borate on the synthesis of liver DNA, using [6-3H]-thymidine, gave unsatisfactory results. It is apparent that borate increases the rate of synthesis of nuclear liver RNA.

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