Abstract
Mitogenic concentrations of recombinant acidic or basic fibroblast growth factor (FGF) stimulated the accumulation of [ 3H]inositol phosphates ([ 3H]IPs) in Swiss 3T3 cells pre-labelled for 48 h with [ 3H]inositol. Maximal effects were obtained at 0.3 ng/ml and 3 ng/ml for basic and acidic FGF, respectively. Higher doses of either factor led to a diminished stimulation. FGF also stimulated 45Ca 2+ release from cells pre-labelled with the isotope. However, FGF-stimulated production of [ 3H]IPs and release of 45Ca 2+ exhibited marked differences when compared with the responses to the peptide mitogen bombesin; the FGF responses were markedly slower and were not inhibited by phorbol esters.
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