Abstract
Administration of different doses of l-thyroxine (T 4) and triiodo- l-thyronine (T 3) in vivo in G. carnosus stimulated the activities of cytochrome oxidase, α-glycerophosphate dehydrogenase (α-GPDH), succinate dehydrogenase (SDH), and Mg 2+ adenosine triphosphatase (Mg 2+ ATPase) and inhibited the activity of malate dehydrogenase (MDH). While a low dose of thiouracil administration produced a stimulatory effect on cytochrome oxidase and α-GPDH activities, a higher dose of thiouracil significantly inhibited the activities of cytochrome oxidase, α-GPDH, SDH, Mg 2+ ATPase, and MDH. Injection of T 4 or T 3 into thiouracil-treated animals significantly restored the stimulatory effect of thyroid hormones on oxidative enzyme activities. It is suggested that thyroid hormones in vivo increase and that thiouracil decreases the oxidative capacity of hepatic mitochondria of G. carnosus.
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