Abstract
The aim of this investigation was to examine whether stimulation of ovarian aromatase activity is affected by gonadotrophic deprivation from birth. Aromatase activity was estimated by incubating ovarian homogenates with 4-androstene 3,17-dione as substrate, followed by ether extraction and estradiol-17β determination by radioimmunoassay, In mice injected daily from birth for 10 days with antiserum neutralizing endogenous gonadotrophin followed by three days stimulation with gonadotrophins, ovarian estradiol-17β production (0.90 ± 0.02 ng/mg ovarian protein) was not significantly different from that in control littermates treated for 10 days with saline followed by 3 days with gonadotrophins. Thus ovarian competence to respond to hormonal challenge by stimulating aromatase activity is acquired independently of postnatal gonadotrophic exposure.
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