Abstract
By means of autoradiography, cellular proliferation in the kidney, induced by unilateral renal decapsulation, was studied in rats over a 72-hour period. Surgical removal of the capsule from one kidney produced a 6-fold increase in incorporation of 3 H-thymidine into nuclei of the proximal and distal tubular epithelium in the decapsulated kidney, as compared to the intact contralateral kidney and as compared to the kidneys of controls that had been subjected to sham operation. The increase in DNA-synthesis began approximately 20 hours after decapsulation, reached a peak after 42 hours, and then declined, but was still above the control levels after 72 hours. As early as 12 hours after decapsulation, there was regenerative proliferation of fibroblasts in epicortical regions of decapsulated kidneys. The intact contralateral kidneys showed no increase in incorporation of 3 H-thymidine into the nuclei of tubular epithelial cells or of capsular fibroblasts.
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