Abstract
Adult rat ventricular cardiomyocytes in culture respond to sub-lethal doses of LPS with increased apoptosis. Our laboratory and others have demonstrated a protective phenotype for neonatal rat ventricular cardiomyocytes (NRVM's) to LPS. Concentrations of LPS far exceeding those necessary to induce TNF-α release do not induce apoptosis in the neonatal cells, although these cells are fully capable or instigating apoptosis in response to multiple other stimuli.
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