Abstract
5-Methylpyrazole-3-carboxylic acid (U-19425) and nicotinic acid, which apparently inhibit lipolysis in vivo as indicated by low plasma FFA and glycerol concentrations, stimulate lipolysis in vitro in adipose tissue removed from fasted rats 30-90 min after treatment. This stimulation is not the result of low initial levels of FFA in adipose tissue. An increased rate of lipolysis is not induced in vitro by preincubating tissue of untreated rats with U-19425. The increase can be blocked in incubated adipose tissue of U-19425-treated animals if U-19425 is added to the incubation medium. The beta-adrenergic blocking agent propranolol, at a concentration which inhibits epinephrine-stimulated lipolysis, does not affect the increase produced by administration of U-19425.
Highlights
5-Methylpyrazole-3-carboxylicacid (U-19425) and nicotinic acid, which apparently inhibit lipolysis in vivo as indicated by low plasma free fatty acid(s) (FFA) and glycerol concentrations, stimulate lipolysis in vitro in adipose tissue removed from fasted rats 30-90 min after treatment
The demonstrated enhancement of lipolysis induced by two antilipolytic agents in adipose tissue appears to be a paradox
It is known that lipid mobilizing hormones, for example ACTH [14] and the catecholamines [15], elevate plasma FFA concentrations and stimulate lipolysis in incubated adipose tissue removed from treated animals
Summary
5-Methylpyrazole-3-carboxylicacid (U-19425) and nicotinic acid, which apparently inhibit lipolysis in vivo as indicated by low plasma FFA and glycerol concentrations, stimulate lipolysis in vitro in adipose tissue removed from fasted rats 30-90 min after treatment. This stimulation is not the result of low initial levels of FFA in adipose tissue. An increased rate of lipolysis is not induced in vitro by preincubating tissue of untreated rats with U-19425. The /3-adrenergic blocking agent propranolol, at a concentration which nhibits epinephrine-stimulated lipolysis, does not affect the increase produced by administration of U-19425
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