Abstract
Effects on insulin secretion of methacholine and bethanechol given systemically and infused into the pancreatic artery were studied in the anesthetized dog. An intramuscular injection of methacholine (0.2 mg/k) resulted in a striking elevation of plasma immunoreactive insulin (IRI) in both pancreatic vein and femoral artery. A rapid intravenous injection of bethanechol (0.05 mg/k) caused a prompt and less prominent increase in pancreatic venous plasma IRI, and a somewhat delayed elevation in femoral artery plasma IRI. A constant infusion of bethanechol (1 μg/k/min) into the pancreatic artery also induced an abrupt and significant rise in pancreatic vein plasma IRI and a delayed augmentation in femoral artery plasma IRI. The increase in plasma IRI in the pancreatic and femoral vessels upon a similar local infusion of methacholine (1 μg/k/mvn) was more conspicuous than on bethanechol infusion. The elevation in plasma IRI by a local infusion of both cholinergic agents was totally blocked by a preceding infus...
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