Abstract
Soymilk was found to stimulate IgM production in human-human hybridoma HB 4 C 5 cells cultured in serum-free ERDF medium supplemented with insulin (I), transferrin (T), ethanolamine (E) and selenine (S) (ITES-ERDF). The activity for immunoglobulin production stimulating factor (IPSF) was recognized in the acid precipitable fraction. The activity was observed in a peak obtained by fractionation on DEAE-Toyopearl 650M. Molecular size of the IPSF was estimened to be approximately 290kDa by gel filtration on Superose 12 HR. The susceptibility of the IPSF to heat or trypsin treatment suggested that it was a proteinous substance. Soymilk also stimulated IgM and IgG production in human lymphocytes cultured in ITES-ERDF medium.
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