Abstract
Comparison was made of the ability of the potent tumor promoter phorbol myristate acetate (PMA), as well as less active PMA analogs and non-phorbol ester tumor promoters, to stimulate superoxide anion radical (O 2 • production by human polymorphonuclear leukocytes (PMN). The rate of O 2 • production was found to correlate with the tumor-promoting activity of the phorbol esters as opposed to their inflammatory activity. Mezerein and telocidin B were slightly better stimulators of O 2 • production than PMA. Acetic acid was inactive. These data are discussed in terms of a possible role for O 2 • and other reactive oxygen species in tumor promotion.
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