Abstract
Human buccal mucosa fibroblasts were exposed in culture to γ-aminobutyric acid (GABA) and the areca alkaloid arecaidine. Both GABA and arecaidine stimulated collagen synthesis and proliferation in a concentration-dependent manner, with arecaidine consistently producing the greater stimulation. Prior exposure to GABA or arecaidine for 5 days caused the cells to become insensitive when challenged with either drug.
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