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Abstract
The effects of glucocorticoids on hormone secretion by human placenta in organ culture were studied. The addition of cortisol resulted in a fourfold increase in human chorionic gonadotropin (hCG) secretion over that in untreated cultures after 144 hours' incubation (P < 0.05), and a twofold increase in hCG was observed in the presence of cortisone (P < 0.01). Dexamethasone stimulated hCG secretion in a dose-response manner (r = 0.9542; P < 0.01). Progesterone, which suppresses hCG under these conditions, decreased the cortisol-enhanced secretion of hCG (r = −0.9794; P < 0.01). No change in the secretion of human chorionic somatomammotropin was observed, but glucocorticoids increased heat-stable alkaline phosphatase activity (P < 0.001). The physiologic significance of glucocorticoid effects on placental hormone synthesis is ducussed.
Published Version
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