Abstract
AbstractFollowing a single intravenous (i.v.) injection of carboplatin-liposomes (REV, HEPC:CH 1: 0.25) into mice peripheral white blood cell (WBC) counts increase to more than 30 000 × 106/ml. This elevation is observed between the 14th and 30th day after administration and significantly higher than normal values are registered even at day 42. Differentiation of WBC reveals both an increase of granulocytes, lymphocytes and monocytes. In parallel, platelets and erythrocytes are reduced moderately. Free carboplatin, empty liposomes or cis-platin-liposomes never caused a similar pharmacological behavior. This increase in peripheral WBC counts is accompanied by a distinct reduction of cell counts in spleens and bone marrow of the same mice. We suppose that carboplatin-liposomes (CPL) are taken up by monocytes/macrophages as their natural target. Within these cells cytokines are induced and released which secondarily lead to an induction of haematopoietic growth factors. This hypothesis is strengthened by the...
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