Abstract
Bacterial lipopolysaccharide can enhance the pinocytosis of horseradish peroxidase in guinea pig macrophages. This increased uptake can be seen as early as 6 hr after incubation in a spinner suspension culture. An equivalent amount of enhanced pinocytosis can be seen if plated, washed peritoneal exudate macrophages are used. Plated guinea pigs PECs, washed five times, were examined for the presence of B cells, and none were found. Thus, LPS appears to stimulate the macrophage directly and does not require a lymphocyte intermediary. The active stimulatory moiety appears to be lipid A, which can be blocked by preincubation of LPS with polymyxin B.
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