Abstract
Extracts of bovine stalk-median eminence fragments (SME) equivalent to 3–5 glands were infused into the carotid artery of young sheep. Plasma GH increased from 4.8 at zero time to 17.7 mμg/ml 30 min after infusion had begun. Infusion of saline or cerebrum extracts had no effect on plasma GH. SME extracts also caused an elevation of plasma glucose and insulin which preceded the rise in GH. Evidence is presented which indicates that the rise in plasma GH levels is not a response to insulin but is a direct effect of a releasing factor in the SME extracts. (Endocrinology 80: 205, 1967)
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