Abstract
The action of erythroid differentiation factor (EDF) on primary culture of rat anterior pituitary cells was examined. EDF stimulates FSH secretoion in a dose dependent manner but not of LH secretion. ED 50 of EDF for FSH secretion was 5 × 10 −10 M, while ED 50 of LHRH for FSH secretion was 5 × 10 −9 M. These data indicate that EDF is a potent agonist for FSH secretion and the biological activity of EDF on anterior pituitary seems to be identical as that of FSH releasing protein (FRP).
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